In the fall of 2015, Rachel Yehuda and her team at the Icahn School of Medicine at Mount Sinai in New York published results of a study looking at the genes of 32 Jewish women and men. All were Holocaust survivors who either had been interned in Nazi concentration camps, forced into hiding during World War II or seen or experience torture. The team also studied the genes of 22 children who were born to Holocaust survivors after the war. Previous studies had found that children of Holocaust survivors have a higher risk of developing post-traumatic stress disorder, depression and anxiety, especially if the parents themselves have PTSD. In a 2015 paper in the journal Biological Psychiatry, Yehuda wrote she had found a genetic explanation for this apparent inheritance of trauma. Her team found changes in the DNA of Holocaust survivors, changes which the scientists said were passed on to offspring. The gene changes in the children could only be attributed to Holocaust exposure in the parents, Yehuda said. What Yehuda described has come to be known as epigenetic inheritance. Its the idea that traumatic experiences affect DNA in ways that are passed on to children and grandchildren, kind of like molecular scars. The idea has taken off, and New Age guru Deepak Chopra is among those who support the finding. But Yehudas study is deeply flawed. What is epigenetics? If DNA contains instructions for making eyes brown and hair curly, epigenetics refers to ways in which those genes are turned on and off. Genes are the blueprint for creating proteins, while epigenetics is the study of how genes are read. At least thats the original definition of epigenetics. Nowadays, the term is also used to describe gene modifications that are passed on from parents to children. Some scientists say we transmit more than our genes. We also pass on molecular switches and information about how those genes should be expressed. One of the most studied epigenetic modifications is DNA methylation, in which small molecules are added to genes, changing the activity of DNA. In a study published in The American Journal of Psychiatry in 2014, Yehuda found that male Holocaust survivors who suffered PTSD had children with higher methylation of a gene involved in stress response. But these changes are exceedingly difficult to interpret. Yehudas team found that if both of the childs parents were Holocaust survivors with PTSD, the child was more likely to have lower methylation of that gene. The problems with Yehudas 2015 study which is still generating headlines stating that trauma is inherited begin with the small study size. Only 32 survivors and 22 of their offspring were studied. Thats a very small group on which to base this theory and a major study flaw that many media outlets overlooked. While the team studied the children of women who lived through the Holocaust, they would have to study the great-grandchildren of survivors to prove actual epigenetic inheritance from mother to offspring. Why must four generations be studied? Baby girls are born with their lifetime supply of eggs. The eggs that made you were present inside your mother when she was a foetus inside your grandmother. Because a pregnant woman already possesses the DNA of her grandchildren and these genes can be affected by things during her pregnancy, the DNA of the great-grandchildren has to be studied to show that epigenetic changes were passed on across generations. Another flaw is that researchers looked at only a tiny number of genes. Further, the study didnt account for the influence of social factors. Children born to Holocaust survivors may grow up listening to accounts of the wars horrors. Josie Glausiusz, a participant in Yehudas 2014 study, raised this point in a recent essay in the Israeli newspaper Haaretz. Glausiuszs father survived the Bergen-Belsen concentration camp. She wrote, I was troubled by a question: How does one separate the impact of horrific stories heard in childhood from the influence of epigenetics? Shes not the only one to raise this question. Researchers have also cast doubt on the studys conclusions based on the small changes in DNA methylation that were seen. Theres also the issue of reverse causation: If DNA methylation is significant, is that change caused by trauma or does the methylation itself increase the risk of PTSD? The week after the study was published, the blog of the Centre for Epigenomics at the Albert Einstein College of Medicine in New York called it the over-interpreted epigenetics study of the week. John Greally, professor of genetics at the college, wrote: The story being told by the Holocaust study is indeed fascinating as a scientific possibility, and will no doubt prompt others to pursue similar studies. Unfortunately, the story is typical of many in the field of epigenetics, with conclusions drawn based on uninterpretable studies. Those who survived the horrors of the Holocaust and other tragedies find themselves asking if they will pass that trauma on to their children. The headlines say, yes but based on a close look at the research, the answer so far is no.
Chicago Tribune, 9 June 2017 ;http://www.chicagotribune.com/news ;