The European consumer goods maker Unilever and the U.S. Environmental Protection Agency have formed a research collaboration aimed at assessing the safety of chemicals found in consumer products without using animal testing. Under the program, the partners will choose five chemicals of mutual interest. EPA will use computer models and high-throughput screening to develop toxicity data on the chemicals. Unilever will use its consumer products knowledge to estimate human exposure to the chemicals. We can then marry these twothe dose and the exposureto measure the health risks, says Russell Thomas, director of EPAs National Centre for Computational Toxicology. In 2012, EPA formed a similar program with the French firm LOréal that targeted 20 chemicals found in LOréal personal care products. With the Unilever collaboration, EPA seeks to introduce elements that have been missing from automated screening, such as incorporating information about how the chemicals being tested are metabolised. Thomas says the collaborations aim to speed up testing of the tens of thousands of chemicals used in the U.S. for which safety information isnt known. Unilever and LOréal hope the strategy will reduce use of animal testing in the development of their products. Jessica Sandler, senior director of the regulatory testing department at People for the Ethical Treatment of Animals, an activist group, notes that EPA already used computation models in its Endocrine Disruptor Screening Program. Sandler says she believes the Unilever collaboration will provide valuable experience with these methods that is needed in order to eventually end the use of animals in painful chemical toxicity tests.
Chemical & Engineering News, 9 September 2015 ;http://pubs.acs.org/cen/news ;