Ammonium sulphamate (or sulfamate) is a white crystalline (sand-like) solid, readily soluble in water with the chemical formula H6N2O3S. 
Ammonium sulphamate is used for flame-retardant textiles and paper, and as herbicide. As a herbicide, ammonium sulphamate is used to control many types of woody plants, trees, herbaceous perennials, and annual broadleaf weeds and grasses. It is a contact herbicide, which means that it injures only those parts of the plant to which it is applied. It is used primarily to control undesired growth along rights-of-way and for general weed and poison ivy control around homes, commercial buildings and fruit orchards. In addition, ammonium sulphamate is used as a fertiliser. 
Routes of Exposure 
The routes of exposure for ammonium sulphamate are:
- skin contact
- eye contact
Health Effects [2,4]
Acute Health Effects
Acute health effects to ammonium sulphamate include irritation to the skin, eyes and nose, cough, gastrointestinal disturbances, respiratory stimulation, prostration, and death.
Chronic Health Effects
No signs or symptoms of chronic ammonium sulphamate exposure have been reported.
- Has not been tested for its ability to cause cancer in animals.
- Has not been tested for its ability to affect reproduction.
First Aid Measures 
- Inhalation: Remove to fresh air. Get medical attention for any breathing difficulty.
- Ingestion: Give several glasses of water to drink to dilute. If large amounts were swallowed, get medical advice.
- Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention if irritation develops.
- Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Get medical attention if irritation persists.
Workplace Controls and Practices 
Unless a less toxic chemical can be substituted for a hazardous substance, engineering controls are most effective means of reducing exposure. The best protection is to enclose operations and / or exhaust on the site spilled chemicals. Isolating operations can also reduce exposure. Use a respirator or protective equipment is less effective than the controls mentioned above, but it is sometimes necessary. Good work practices can help to reduce hazardous exhibitions. The following work practices are recommended:
- Workers whose clothing has been contaminated by ammonium sulphamate should quickly change into clean clothes.
- Do not take contaminated work clothes home. Family members could be exposed.
- Contaminated work clothes should be washed ensure workers have been informed of the risks of exposure to ammonium sulphamate.
- Eye wash fountains should be provided in the immediate work area in case of emergency.
- If the possibility of skin exposure, emergency showers should be provided.
- On skin contact with ammonium sulphamate, immediately wash or shower to remove the chemical.
- Do not eat, smoke, drink or when ammonium sulphamate handled, processed or stored, since the chemical can be ingested.
- Wash hands thoroughly before eating, drinking, smoking or using the toilet.
- Use a vacuum or a wet method to reduce dust during cleanup up. Do not dry sweep.
Personal Protective Equipment 
- Personal Respirators (NIOSH Approved): For conditions of use where exposure to the dust or mist is apparent, a half-face dust/mist respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
- Skin Protection: Wear protective gloves and clean body-covering clothing.
- Eye Protection: Use chemical safety goggles. Maintain eye wash fountain and quick-drench facilities in work area.
- OSHA: The Occupational Safety & Health Administration permissible exposure limits for ammonium sulphamate are 10mg/m3 (total dust) and 5mg/m3 (respirable fraction) as an 8 hour time weighted average concentration;
- NIOSH: The National Institute of Occupational Safety & Health has established a recommended exposure limit of 10mg/m3 (total dust) and 5mg/m3 (respirable fraction) as an 8 hour time weighted average;
- ACGIH: The American Conference of Governmental Industrial Hygienists has assigned ammonium sulphamate a threshold limit value of 10mg/m3 as a time weighted average for an 8-hour workday.
- Safe Work Australia: Safe Work Australia has established a time weighted average concentration of 10mg/m3 for ammonium sulphamate.