ECHA consults on 25 testing proposals

The European Chemicals Agency (ECHA) has called for information on 25 testing proposals involving vertebrate animals. Scientifically valid information and studies from third parties should be submitted to the agency by 20 April 2012. The substances are as follows: Substance Name EC Number CAS Number Hazard Endpoint for which vertebrate testing was proposed 2,5-Furandione, dihydro-, mono-C15-20-alkenyl derivs. //Note: Consultation previously done for Pre-natal developmental toxicity due to incorrect indication in the dossier. Consultation needs to be reopened for Two-generation reproductive toxicity. 272-221-2 68784-12-3 Reproductive toxicity (two-generation reproductive toxicity) [1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide 246-678-3 25155-25-3 Sub-chronic toxicity (90-day): oral Bioaccumulation aquatic / sediment Reproductive toxicity (pre-natal developmental toxicity) A mixture of: tetrasodium-phosphonoethane-1,2-dicarboxylate; hexasodium-phosphonobutane-1,2,3,4-tetracarboxylate 410-800-5 Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) Fatty acids, tall-oil, oligomeric reaction products with maleic anhydride and rosin, calcium magnesium zinc salts || Note: testing proposed with Rosin, fumerated (CAS 65997-04-8) 500-451-8 160901-14-4 Reproductive toxicity (pre-natal developmental toxicity) Phosphonium, tetrakis(hydroxymethyl)-, chloride (1:1), reaction products with 1-tetradecanamine and urea 436-230-7 359406-89-6 Sub-chronic toxicity (90-day): oral Reaction mass of 1-phenyloctadecane-1,3-dione and phenylicosane-1,3-dione 915-316-2 Reproductive toxicity (pre-natal developmental toxicity) Resin acids and Rosin acids, calcium salts || Note: testing proposed with rosin (EC 232-475-7; CAS 8050-09-7) 232-694-8 9007-13-0 Reproductive toxicity (pre-natal developmental toxicity) Resin acids and Rosin acids, calcium zinc salts || Note: testing proposed with rosin (EC 232-475-7; CAS 8050-09-7) 269-825-3 68334-35-0 Reproductive toxicity (pre-natal developmental toxicity) Resin acids and Rosin acids, esters with glycerol || Note: testing proposed with Resin acids and Rosin acids, esters with pentaerythritol (CAS 8050-26-8) 232-482-5 8050-31-5 Reproductive toxicity (pre-natal developmental toxicity) Resin acids and Rosin acids, esters with pentaerythritol 232-479-9 8050-26-8 Reproductive toxicity (pre-natal developmental toxicity) Resin acids and Rosin acids, esters with triethylene glycol || Note: testing proposed with Resin acids and Rosin acids, esters with pentaerythritol (CAS 8050-26-8) 232-478-3 8050-25-7 Reproductive toxicity (pre-natal developmental toxicity) Resin acids and Rosin acids, hydrogenated, esters with glycerol || Note: testing proposed with Resin acids and Rosin acids, esters with pentaerythritol (EC 232-479-9; CAS 8050-26-8) 266-042-9 65997-13-9 Reproductive toxicity (pre-natal developmental toxicity) Resin acids and Rosin acids, hydrogenated, esters with pentaerythritol || Note: testing proposed with Resin acids and Rosin acids, esters with pentaerythritol (EC 232-479-9; CAS 8050-26-8) 264-848-5 64365-17-9 Reproductive toxicity (pre-natal developmental toxicity) Resin acids and Rosin acids, magnesium salts || Note: testing proposed with rosin (EC 232-475-7; CAS 8050-09-7) 270-461-2 68440-56-2 Reproductive toxicity (pre-natal developmental toxicity) Resin acids and Rosin acids, potassium salts || Note: testing proposed with rosin (EC 232-475-7; CAS 8050-09-7) 263-142-4 61790-50-9 Reproductive toxicity (pre-natal developmental toxicity) Resin acids and Rosin acids, sodium salts || Note: testing proposed with rosin (EC 232-475-7; CAS 8050-09-7) 263-144-5 61790-51-0 Reproductive toxicity (pre-natal developmental toxicity) Rosin 232-475-7 8050-09-7 Reproductive toxicity (pre-natal developmental toxicity) Rosin, fumarated 266-040-8 65997-04-8 Reproductive toxicity (pre-natal developmental toxicity) Rosin, fumarated, reaction products with formaldehyde || Note: testing proposed with Rosin, fumerated (CAS 65997-04-8) 305-795-0 95009-65-7 Reproductive toxicity (pre-natal developmental toxicity) Rosin, hydrogenated || Note: testing proposed with Rosin (CAS 8050-09-7) 266-041-3 65997-06-0 Reproductive toxicity (pre-natal developmental toxicity) Rosin, maleated || Note: testing proposed with Rosin, fumerated (CAS 65997-04-8) 232-480-4 8050-28-0 Reproductive toxicity (pre-natal developmental toxicity) Rosin, reaction products with formaldehyde || Note: testing proposed with rosin (EC 232-475-7; CAS 8050-09-7) 293-659-0 91081-53-7 Reproductive toxicity (pre-natal developmental toxicity) Slags, steelmaking, elec. furnace (stainless/high alloy steel production) 932-476-9 Sub-chronic toxicity (90 day): inhalation

European Chemicals Agency, 6 March 2012 ;http://echa.europa.eu ;