Third draft of revised guidance on registration passes to Caracal

The European Chemicals Agency (ECHA) recently passed the third draft of the revised Guidance on registration to the Competent Authorities for REACH and CLP (Caracal). Comments made by ECHA’s Committees are posted on the agency’s website. Further information is available at: Draft~s ~tGerman researcher investigates reproductive toxicity requirements under REACH A German industry researcher has proposed a new approach for the assessment of reproductive toxicity under REACH, in a paper published in Regulatory Toxicology and Pharmacology. Currently, REACH regulation requires the evaluation of reproductive toxicity in OECD approved screening tests for substances above 10 t/y, using according to OECD TG 421 and 422. However, the researcher argues that registrant should have the possibility to file a dossier for such substances on the basis of data from a developmental toxicity study, plus a full-scale subacute toxicity study conducted according to OECD guidelines. The paper states that this proposed new test strategy takes into account overall considerations of duty of care and animal welfare, by potentially reducing the number of experimental animals used. According to the author, registrants should be allowed to select between either the existing approach or the new approach proposed. Further information is available at: Abstract

Chemical Watch, 5 April 2012 ; ;