EU safety evaluation of food enzyme D-psicose 3-epimerase from Genetically Modified Corynebacterium glutamicum


On October 18th, 2021, the European Food Safety Authority published an assessment “Safety evaluation of the food enzyme d‐psicose 3‐epimerase from the genetically modified Corynebacterium glutamicum strain FIS002”.

The scope of the data assessment highlights the following:

The food enzyme is used in processing fructose to produce a specialty carbohydrate d‐allulose;

Genotoxicity tests did not raise a safety concern;

Under the intended conditions of use, the risk of allergic sensitization and elicitation reactions by dietary exposure is low;

The food enzyme preparation contains multiple copies of an antimicrobial resistance gene, which is considered a hazard;

The available results concluded that the identified hazard associated with the food enzyme d‐psicose 3‐epimerase produced with the genetically modified C. glutamicum strain FIS002 will not result in a risk.


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Selerant, 20 October 2021