Reference doses for industrial use of cobalt salts

Cobalt salts are used widely throughout industry as industrial catalysts, in pigments, dyes, inks, as additives to soils and animal feeds, and in dietary supplements. The European Chemicals Agency’s (ECHA) Committee for Risk Assessment (RAC) has concluded that five water soluble cobalt salts should be considered genotoxic carcinogens and are to be assessed using a non-threshold approach. This is the result of a study of the five cobalt salts identified as substances of very high concern (SVHC) under the EU REACH Regulation and consequently placed on the candidate list for authorisation. The five substances are cobalt(II) sulphate, cobalt dichloride, cobalt(II) dinitrate, cobalt(II) carbonate and cobalt(II) diacetate. As sufficient documentation was lacking to identify thresholds, a non-threshold approach is considered the most cautious for assessing genotoxic carcinogens. Using the non-threshold approach, the following dose-response relationships have been derived: Worker exposure (8 h/d): Excess risk = exposure level (mg Co/m3) x 1.05 (mg Co/m3)-1 General population exposure (24 h/d): Excess risk = exposure level (mg Co/m3) x 5.88 (mg Co/m3)-1 Further information is available at: Establishing a Reference Dose Response Relationship for Carcinogenicity of Five Cobalt Salts

DHI Newsletter, 28 September 2016 ;http://www.dhigroup.com ;