Considerable controversy surrounds the carcinogenic potential of asphalt and tar. Since minority individuals may have had relatively high historical exposures, the authors investigated asphalt and tar exposure and lung cancer risk among African Americans and Latino Americans. A case-control study of lung cancer among African Americans and Latino Americans in the San Francisco Bay area (422 cases, 894 controls) was conducted. A questionnaire was used to obtain detailed work histories and exposure information. Self-reported exposures to asphalt and tar as well as other factors (e.g., smoking, automobile exhaust, and asbestos) were evaluated as predictors of lung cancer risk. Potential effect modification by cytochrome P 450 (CYP) 1A1 was also explored. Self-reported duration of exposure to asphalt and tar was associated with a statistically significant excess risk of lung cancer in the overall population (OR: 1.11, 95% CI: 1.01-1.22), evaluating risk per yr of exposure. Years of exposure to automobile exhaust (OR: 1.02, 95% CI: 1.00-1.05) and asbestos (OR:1.04, 95% CI: 1.02-1.06) were also associated with statistically significant elevations in risk. In Latino Americans, the lung cancer risks associated with polycyclic aromatic hydrocarbon-related exposures were consistently higher in the CYP1A1 wild-type subjects as compared to the variant genotype subjects, and the interaction was statistically significant for smoking and the CYP1A1 M2 polymorphism (Pvalue interaction) 0.02). The authors concluded that the findings from the present study are consistent with the literature suggesting that exposure to asphalt and tar may increase risk of lung cancer. However, it was not possible to separate the effects and asphalt and tar in this study.
Authors: McClean, Michael D.; Kelsey, Karl T.; Sison, Jennette D.; Quesenberry, Charles P., Jr.; Wrensch, Margaret R.; Wiencke, John K. ;Full Source: American Journal of Industrial Medicine 2011, 54(11), 811-818 (Eng) ;