Acquired deficiency diseases with vitamin K-dependent coagulation factor caused by anticoagulant rodenticides poisoning – clinical analysis of 46 cases

Understanding of anticoagulant rodenticides poisoning was enhanced to improve levels of its diagnosis and treatment. The clinical features, laboratory examination and curative effect of vitamin K-dependent coagulation factor (VKDCFs) caused by anticoagulant rodenticides poisoning were analysed retrospectively. Haemorrhage in multiple sites, such as hematuria, skin and mucous haemorrhage, was the first symptom of the patients. The activated partial thromboplastin time (aPTT) and prothrombin time (PT) and INR were obviously shortened in the patients at day 1, day 3 and day 7 post-treatment (P<0.01) compared with those of prior treatment. And the levels of clotting factors II, VII,IX and X were significantly elevated in the patients at day 3, day 7 post-treatment compared with those of prior treatment (P<0.01). When unexplained haemorrhage in multiple sites accompanying with much prolonged PT and aPTT, VKDCFs caused by anticoagulant rodenticides poisoning should be taken into account and the long term and sufficient dose of vitamin K is needed for the treatment.

Authors: Wang, Zhen; Liu, Zhongwen; Zhang, Yin; Zang, Yuzhu; Yang, Jing; Guo, Jianmin; Zhu, Zunmin; Yuan, Xiaoli; Lei, Pingchong ;Full Source: Xueshuan Yu Zhixuexue 2011, 17(4), 166-168, 182 (Ch) ;