Adverse effects of BDE-47 on life cycle parameters, antioxidant system, and activation of MAPK signalling pathway in the rotifer Brachionus koreanus

2,2′,4,4′-Tetrabromodiphenyl ether (BDE-47) is widely dispersed endocrine disrupting chemicals (EDCs) in the aquatic ecosystem. Due to its devastating effect on marine organisms and insufficient database on toxicology, the authors investigated the adverse effects of BDE-47 on life parameters and antioxidant defence system following the reactive oxygen species (ROS) production in the monogonont rotifer Brachionus koreanus. In B. koreanus, the reduction in life cycle, fecundity, and population growth were observed in response to BDE-47. 50?g/L BDE-47 significantly reduced (P<0.05) life expectancy and net reproductive rate. In response to 10-50?g/L BDE-47 exposure, the oxidative stress was elicited via the generation of ROS, while the antioxidant related enzymes (e.g. glutathione S-transferase [fusion_builder_container hundred_percent="yes" overflow="visible"][fusion_builder_row][fusion_builder_column type="1_1" background_position="left top" background_color="" border_size="" border_color="" border_style="solid" spacing="yes" background_image="" background_repeat="no-repeat" padding="" margin_top="0px" margin_bottom="0px" class="" id="" animation_type="" animation_speed="0.3" animation_direction="left" hide_on_mobile="no" center_content="no" min_height="none"][GST] and glutathione reductase [GR]) have demonstrated significant activity levels (P<0.05) to further alleviate the oxidative stress in a concentration dependent manner. Furthermore, transcript profiles of antioxidant function (GST-A, -O, and -S1-S8)-related genes have shown the significant increase over 24h in response to BDE-47 (0, 10, 25, and 50?g/L). As for MAPK signalling pathway analysis, up-regulation of their activities was observed at 25?g/L BDE-47 but their activities have reduced at adult NOEC concentration of 50?g/L. This study provides a better understanding of the effects of BDE-47 on life parameters, molecular defence system, and activation of MAPK signalling pathway against generated oxidants in the rotifer. Authors: Park JC, Han J, Lee MC, Kang HM, Jeong CB, Hwang DS, Wang M, Lee JS. ;Full Source: Aquatic Toxicology. 2017 Feb 27; 186:105-112. doi: 10.1016/j.aquatox.2017.02.025. [Epub ahead of print] ;[/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]