Antifibrotic treatment response and prognostic predictors in patients with idiopathic pulmonary fibrosis and exposed to occupational dust


Idiopathic Pulmonary Fibrosis (IPF) is an aggressive interstitial lung disease with an unpredictable course. Occupational dust exposure may contribute to IPF onset, but its impact on antifibrotic treatment and disease prognosis is still unknown. In the present study, the authors evaluated clinical characteristics, respiratory function and prognostic predictors at diagnosis and at 12-month treatment of pirfenidone or nintedanib in IPF patients according to occupational dust exposure. A total of 115 IPF patients were recruited. At diagnosis, the authors collected demographic, clinical characteristics, occupational history. Pulmonary function tests were performed and two prognostic indices [Gender, Age, Physiology (GAP) and Composite Physiologic Index (CPI)] calculated, both at diagnosis and after the 12?-month treatment. The date of long-term oxygen therapy (LTOT) initiation was recorded during the entire follow-up (mean?=?37.85, range 12-60?months). At baseline, patients exposed to occupational dust [? 10?years (n?=?62)] showed a lower percentage of graduates (19.3% vs 54.7%; p?=?0.04) and a higher percentage of asbestos exposure (46.8% vs 18.9%; p 0.002) than patients not exposed [

Authors: Casillo V, Cerri S, Ciervo A, Stendardo M, Manzoli L, Flacco ME, Manno M, Bocchino M, Luppi F, Boschetto P.
; Full Source: BMC Pulmonary Medicine. 2019 Sep 5;19(1):170. doi: 10.1186/s12890-019-0930-7.