This study investigated the association between occupational exposure to trichloroethylene (TCE) and kidney cancer, as this correlation has been questioned. The incidence of cancers was studied in a dynamic cohort of 997 male workers who for many years had been occupationally exposed to TCE. During a 50-year observation period, 13 cases of kidney cancer were observed (7.5 expected) with a standardised incidence ratio of 1.7 and a 95% confidence interval of 1.0 to 3.0. Four other cases, not included in the SIR analysis, were also observed. Long-term TCE exposure was positively confirmed for 14 of the 17 incident cases. There is reason to assume that the remaining cases also had been exposed to TCE. The authors concluded that the present study supports the view that TCE is a kidney carcinogen.
Authors: Buhagen M, Grnskag A, Ragde SF, Hilt B. ;Full Source: Journal of Occupational & Environmental Medicine. 2016 Jul 26. [Epub ahead of print] ;