Association of polymorph variants of CYP1A2 and CYP1A1 genes with reproductive and thyroid diseases in female workers of petrochemical industry

In this present study, the authors have presented the results obtained in a study of relationships between polymorph variants of CYP1A1 and CYP1A2 genes with reproductive and thyroid diseases risk in female workers of the petrochemical industry, when compared with a reference group. Variants TD and DD of CYP1A2 gene appeared to be associated with nodes formation in uterus and breast in female workers and reference group females. Following liability markers are obtained homozygous in rare allele genotype CC of CYP1A1 gene for reproductive and thyroid disease (fibrous cystic mastopathy and nodular goitre), heterozygous genotype AG of CYP1A1 gene in uterine myoma and fibrous cystic mastopathy, homozygous in deleted T genotype of CYP1A2 gene in autoimmune thyroiditis. The authors concluded that occupational hazards and long length of service at hazardous industries increase effects of rare alleles of the genes studied.

Authors: Irmyakova, A. R.; Kotchetova, O. V.; Gainoullina, M. K.; Sivotchalova, O. V.; Victorova, T. V. ;Full Source: Meditsina Truda i Promyshlennaya Ekologiya 2012, (5), 41-48 (Russian) ;