Biological effects of new-generation dialkyl phosphinate flame retardants and their hydrolysates in BALB/C mice

Aluminium methylcyclohexylphosphinate (AMHP), calcium methylcyclohexylphosphinate (CMHP), aluminium diethylphosphinate (ADEP), and aluminium methylethylphosphinate (AMEP) are organic dialkyl phosphinates (DPs) and emerging phosphorus-based flame retardants. The broad-spectrum DPs flame retardants occupy high-end industrial markets, but their ecologic risk has been reported rarely. By exposing male BALB/c mice to DPs and dialkyl phosphinic acids, the authors studied the toxic effects of these chemicals, and measured AMHP and methylcyclohexylphosphinic acid (MHPA) in blood and faeces. The results showed that DPs and their main hydrolysates had mild toxicity in BALB/c mice. Exposure to 10 and 50 mg/kg/d of AMEP and ADEP caused mild hepatotoxicity in mice. Toxicity of CMHP was in the liver and kidneys. Toxicity of AMHP and its hydrolysate MHPA was low and affected the liver. The authors concluded that these data suggest that AMHP has lower toxicity than the other DPs tested.

Authors: Bao J, Liu Y, Li L, Chen M, Liu J, Niu Y, Liu J, Liang Y. ;Full Source: Environmental Toxicology. 2017 Jan 13. doi: 10.1002/tox.22383. [Epub ahead of print] ;