Blood lead levels and cumulative blood lead index (CBLI) as predictors of late neurodevelopment in lead poisoned children

This study aimed to find the best lead exposure assessment marker for children. The authors recruited 11 children, calculated a cumulative blood lead index (CBLI) for the children, measured their concurrent BLL, assessed their development, and measured their bone lead level. The results showed that 9 of 11 children had clinically significant neurodevelopment problems. CBLI and current blood lead level, but not the peak lead level, were significantly or marginally negatively associated with the full-scale IQ score. The authors concluded that lead exposure at a younger age significantly impacts a child’s later neurodevelopment. CBLI may be a better predictor of neurodevelopment than are current or peak blood lead levels.

Authors: Nie, Linda H.; Wright, Robert O.; Bellinger, David C.; Hussain, Javed; Amarasiriwardena, Chitra; Chettle, David R.; Pejovicc-Milicc, Ana; Woolf, Alan; Shannon, Michael ;Full Source: Biomarkers [online computer file] 2011, 16(6), 517-524 (Eng) ;