This study aimed to find the best lead exposure assessment marker for children. The authors recruited 11 children, calculated a cumulative blood lead index (CBLI) for the children, measured their concurrent BLL, assessed their development, and measured their bone lead level. The results showed that 9 of 11 children had clinically significant neurodevelopment problems. CBLI and current blood lead level, but not the peak lead level, were significantly or marginally negatively associated with the full-scale IQ score. The authors concluded that lead exposure at a younger age significantly impacts a child’s later neurodevelopment. CBLI may be a better predictor of neurodevelopment than are current or peak blood lead levels.
Authors: Nie, Linda H.; Wright, Robert O.; Bellinger, David C.; Hussain, Javed; Amarasiriwardena, Chitra; Chettle, David R.; Pejovicc-Milicc, Ana; Woolf, Alan; Shannon, Michael ;Full Source: Biomarkers [online computer file] 2011, 16(6), 517-524 (Eng) ;