Childhood Determination of Hodgkin lymphoma among U.S. servicemen

Hodgkin lymphoma (HL) in young adults is inexplicably linked to economic development. The authors conducted a nested case-control study of the 656 servicemen with HL diagnosed between ages 17-32 while on active duty in the U.S. military during 1950-68. Controls, chosen randomly from the servicemen on duty at the time, were matched on service, birth year, and induction date. Information came from pre-induction records and military records for the period ending at onset or the equivalent date. Risk was independently increased with small sib-ship size, (OR 2.3, CI 1.6-3.5) low birth order (OR1.9, CI1.4-2.6) and an interval of at least 5 years between birth and that of a previous or subsequent sibling (OR 2.1 CI1.5-3.1.) Other factors independently and significantly associated with elevated risk of HL were: tallness, high BMI, more education (but not higher income) in the County of birth, BB or AB blood type, past infectious mononucleosis, (but a deficit of other childhood viral infections). Early fatherhood conveyed high risk (OR 2.6 CI 1.4-4.8), especially if with a high-risk sibling configuration. Factors unrelated to risk included personal education, pre-induction or military occupation, induction test score, and rank. Findings were similar for nodular sclerosis and mixed cell histological subtypes. The authors concluded that protection from the environment in childhood, but not in adulthood, increase the likelihood of young adult HL, which may result from non-specific isolation from early infections and/or exposure to late infection by a specific but unidentified ubiquitous childhood virus.

Authors: Mack TM, Norman JE Jr, Rappaport E, Cozen W. ;Full Source: Cancer Epidemiology, Biomarkers & Prevention. 2015 Aug 31. pii: cebp.0145.2015. [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][Epub ahead of print] ;[/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]