Circulating levels of perfluoroalkyl substances and left ventricular geometry of the heart in the elderly

Some persistent organic pollutants (POPs) such as hexachlorobenzene (HCB) and some polychlorinated biphenyls (PCBs) have been shown to interfere with myocardial function and geometry. In this study, the authors investigated another group of POPs: per- and polyfluoroalkyl substances (PFASs) were also associated with alterations in left ventricular geometry. 801 subjects aged 70?years were investigated in a cross-sectional study within the scope of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Eight PFASs were detected in >75% of participantsĀ“ plasma by ultra-performance liquid chromatograph/tandem mass spectrometry. Left ventricular geometry was determined by echocardiography. Multivariable linear regression was used to investigate the associations between PFASs and left ventricular geometry of the heart after exclusion of subjects with previous myocardial infarction (n?=?72). When adjusting for multiple comparisons, none of the eight PFASs evaluated were significantly related to left ventricular mass. However, perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA) were related to relative wall thickness (RWT) in a negative fashion (p?

Authors: Mobacke I, Lind L, Dunder L, Salihovic S, Lind PM. ; Full Source: Environment International. 2018 Apr 2; 115:295-300. doi: 10.1016/j.envint.2018.03.033. [Epub ahead of print]