Concentrations of endocrine disrupting chemicals in newborn blood spots and infant outcomes in the upstate KIDS study

Novel methodologies to quantify infant exposures to endocrine disrupting chemicals (EDCs) for population-based studies are needed. In this study, the authors used newborn dried blood spots to quantify three EDCs and their associations with infant outcomes in the Upstate KIDS Cohort. Bisphenol A (BPA), perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) were measured in 2071 singleton and 1040 twin infants born to mothers in New York State. The authors log transformed concentrations after rescaling by their standard deviations and modelled each in relation to gestational age, birthweight, length, head circumference and Ponderal Index (PI) using linear regression techniques. All models were adjusted for maternal age, body mass index, education, infertility treatment and parity. Generalised estimating equations with robust standard errors were used to assess the associations for twins. Chemicals were largely quantified above the limits of detection (>99% for PFOS and PFOA; 90% for BPA). Overall, no significant associations were observed between PFASs and birth size irrespective of plurality of birth. However, among twins, BPA was associated with decreases in gestational age (adjusted ??=?-0.09?weeks; 95% Confidence Interval (CI): -0.16, -0.02) and birthweight (adjusted ??=?-32.52?g; 95% CI: -60.99, -4.05), head circumference (adjusted ??=?-0.18?cm; 95% CI: -0.38, -0.02) and increased PI in singletons (adjusted ??=?0.02?cm; 95% CI: 0.004, 0.04). The authors concluded that they observed negative associations between BPA and birth size in twins. These findings demonstrate the feasibility of newborn dried blood spots for quantifying neonatal exposure at the population level.

Authors: Bell EM, Yeung EH, Ma W, Kannan K, Sundaram R, Smarr MM, Buck Louis GM. ; Full Source: Environment International. 2018 Sep 13;121(Pt 1):232-239. doi: 10.1016/j.envint.2018.09.005. [Epub ahead of print]