For more than 10 years, risk assessment of bisphenol A (BPA) has been debated at an international level. In 2008, the United States National Toxicology Program (NTP) expressed some concern for adverse effects, at current level of exposure to BPA, on developmental toxicity. In this context, the French Food Safety Agency (AFSSA) decided to review the toxicity data on BPA with a special focus on this endpoint at doses below 5 mg/kg bw/day (the no observed adverse effect level set by different regulatory bodies). This study summarises the conclusions of a collective assessment conducted by an expert Working Group from AFSSA. Studies were classified into 3 groups: finding no toxicity, reporting results not considered to be of concern and indicating warning signals. The term “warning signal” means that no formal conclusion can be drawn regarding the establishment of a health based guidance value but the study raises some questions about the toxicity of BPA at low doses. It was concluded that studies are needed to ascertain the significance for human health of these warning signals and to be able to propose new methodologies for assessing the risks associated with low doses of BPA and more generally of endocrine disruptors.
Authors: Arnich, Nathalie; Canivenc-Lavier, Marie-Chantal; Kolf-Clauw, Martine; Coffigny, Herve; Cravedi, Jean-Pierre; Grob, Konrad; Macherey, Anne-Christine; Masset, Dominique; Maximilien, Remi; Narbonne, Jean-Francois; Nesslany, Fabrice; Stadler, Jeanne; Tulliez, Jacques ;Full Source: International Journal of Hygiene and Environmental Health 2011, 214(3), 271-275 (Eng) ;