Cytotoxicity of serum protein-adsorbed visible light photocatalytic Ag/AgBr/TiO2 nanoparticles

Photocytotoxicity of visible light catalytic Ag/AgBr/TiO2 nanoparticles (NPs) was examined both in vitro and in vivo. Their crystals structures, atom compositions, and light absorption property were examined by X-ray diffraction (XRD) patterns, X-ray photoelectron (XPS) intensities, and UV-visible (UVvis) diffuse reflectance spectroscopic tools. The Ag/AgBr/TiO2 appeared to be well internalised in human carcinoma cells as evidenced by transmission electron microscopy (TEM). The cytotoxicity of cetylmethylammonium bromide (CTAB) appeared to be significantly reduced by adsorption of serum proteins in the cellular medium on the NP surfaces. NPs, we observed a 40-60% selective decrease of cell viability. Ag/AgBr/TiO2 NPs were found to eliminate xenograft tumours significantly by irradiating visible light in vivo for 10 minutes.

Authors: Seo, Ji Hye; Jeon, Won Il; Dembereldorj, Uuriintuya; Lee, So Yeong; Joo, Sang-Woo ;Full Source: Journal of Hazardous Materials [online computer file] 2011, 198, 347-355 (England) ;