Demonstration of subclinical early neprotoxicity induced by occupational exposure to Silica among workers in pottery industry

2020-04-01

BACKGROUND:

For many years, several studies drew attention to the possible nephrotoxic effects of silica and distinct renal dysfunction involving glomerular and renal tubules in workers exposed to silica.

OBJECTIVE:

To determine the early signs of subclinical nephrotoxic effects among some Egyptian workers exposed to silica in the pottery industry.

METHODS:

This study was carried out in El-Fawakhir handicraft pottery area, in Greater Cairo, Egypt. The studied population included 29 non-smoking male workers occupationally exposed to silica in addition to 35 non-smoking administrative male subjects who represented the comparison group in the study. Measured urinary parameters were concentrations of total protein (TP), microalbumin (Malb), activities of alkaline phosphatase (ALP), ?-glutamyl transferase (?-GT), lactate dehydrogenase (LDH), kidney injury molecule-1 (KIM-1), and silicon (Si).

RESULTS:

Silica-exposed workers showed signi?cantly (p<0.05) increased levels of urinary TP, Malb, ALP, ?-GT, LDH, and KIM-1 compared with the comparison group. Among the silicaexposed group, increased urinary Si levels were positively and signi?cantly correlated (Spearman's ?>0.60, p<0.001 for all variables) with the elevated urinary proteins (including KIM-1) and enzymes levels. All measured urinary parameters were positively and signi?cantly correlated (?>0.75, p<0.001 for all variables) with the duration of work among exposed subjects. No significant correlation was observed between the measured variables and the age of workers.

CONCLUSION:

There is associated subclinical glomerular and tubular affection among silicaexposed workers, which is related to the duration and intensity of exposure.

Authors: Mourad BH, Ashour YA
; Full Source: The international journal of occupational and environmental medicine. 2020 Apr;11(2):85-94. doi: 10.34172/ijoem.2020.1886.