In this study, the authors developed and validated a method for the assessment of thirteen separate trace and toxic elements using Inductively Coupled Plasma-Mass Spectrometry (ICP-MS). Included elements were as follows: aluminium, chromium, manganese, iron, cobalt, nickel, copper, zinc, arsenic, molybdenum, cadmium, tungsten, and lead. The measurements of all elements in urine samples were conducted using ICAP-Q ICP-MS in a single method. The performance characteristics of the assay were determined according to clinical laboratory standards. The assay was linear in the concentration range of 1.0 to 1000.0 µg/litre for all elements. The method was precise and accurate with limits of quantitation of 1 µg/litre for chromium, manganese, cobalt, nickel, copper, cadmium, tungsten, and lead; 2 µg/litre for iron and arsenic; 5 µg/litre for aluminium; and 50 µg/litre for zinc. This method has successfully been used for the assessment of all thirteen elements included in urine and has been shown to be effective as a simple, precise, and sensitive analytical technique for biological monitoring of urine samples.
Authors: Velez-Quinones MA, Xu H, Vo N, Gaitens JM, McDiarmid MA, Lewin-Smith MR, Strathmann FG. ; Full Source: Current Protocols in Toxicology. 2018 Sep 20:e58. doi: 10.1002/cptx.58. [Epub ahead of print]