Development of shellfish allergy after exposure to dual immune checkpoint blockade

Hepatocellular carcinoma (HCC) is a major health problem worldwide with limited systemic therapies available. Immunotherapy is a fast-moving field that is quickly evolving as a treatment for HCC with three recent clinical trials published treating HCC with immune checkpoint inhibitors with promising results. Checkpoint inhibition may lead to a unique adverse event profile with the potential to cause immune-related adverse events by unbalancing the immune system. In this study, the authors report a case of a 61-year-old male with advanced HCC who developed a shellfish allergy after completing three cycles of combination of tremelimumab and durvalumab therapy.

Authors: Brown ZJ, Heinrich B, Greten TF. ; Full Source: Hepatic Oncology. 2018 Feb 9;5(1): HEP02. doi: 10.2217/hep-2017-0021. eCollection 2018 Jan.