Dioxin Exposure in the Manufacture of Pesticide Production as a Risk Factor for Death from Prostate Cancer: A Meta-analysis

In pesticide exposure groups such as farmers, the risk of prostate cancer was increased, although the report of the cause of evidence is limited. The authors selected chlorophenol compounds as an important group of the contaminated pesticide with highly toxic 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD). This meta-analysis, the risk of death from prostate cancer was analysed. PubMed, Scopus, Scholar Google and web of Sciences until 2016 were searched. The standardised mortality rate (SMR) and 95% confidence intervals (CI) were obtained from the studies. Statistical heterogeneity was tested with Cochrane Q test and I2 index. Egger test was used for evaluating publication bias. Random or fixed-effects models and meta-regression were also used in the analysis. Moreover, Cochrane tool was used to assess the risk of bias. Five available papers consist of 28706 exposed populations were assessed. Overall standardised mortality rate as combined result of prostate cancer risk from the fixed model was 1.2 (95% confidence interval (CI) 1.02 to 1.42, P=0.027). Some biases are more probable in these studies such as confounding by indication, loss to follow up and misclassification. The authors concluded that a contaminated pesticide with dioxins between other pesticides is an important risk factor for prostate cancers.

Authors: Kabir A, Zendehdel R, Tayefeh-Rahimian R. ; Full Source: Iran Journal of Public Health. 2018 Feb;47(2):148-155.