Effect of 2-phenoxyethanol on safety and immunogenicity of bulk acellular pertussis vaccine and acellular DTP

The effects of 2-phenoxyethanol on safety and immunogenicity of bulk acellular pertussis (aP) vaccine and acellular diphtheria-tetanus-pertussis vaccine (DTP) (DTaP) were investigated. The bulk of aP was formulated using 2-phenoxyethanol and thimerosal as stabilisers and prepared into DTaP, respectively. The safety and immunogenicity of bulk aP and DTaP, as well as the bacteriostatic effect of 2-phenoxyethanol in DTaP, were evaluated. The bulks of aP prepared using 2-phenoxyethanol and thimerosal as stabilisers showed no significant difference in safety and immunogenicity. All the indexes of DTaP using 2-phenoxyethanol as stabiliser met the requirements in Chinese Pharmacopoeia (Vol. III, 2005 edition). Both the DTaP before and after storage at 37°C for one month were qualified in sterility test. 2-Phenoxyethanol might be used as a stabiliser of DTaP instead of thimerosal.

Authors: Hu, Huiqiong; Pan, Hailong; Gu, Jie; Huang, Kai; Xu, Yongge; Yang, Guoyou; Qin, Min. ;Full Source: Zhongguo Shengwu Zhipinxue Zazhi 2011, 24(10), 1165-1167 (China). ;