Effects of Glyphosate and Roundup™ on the mammalian nervous system: A review


Glyphosate is the active ingredient in Roundup™, the most widely used herbicide in the world. Glyphosate targets an essential enzyme in plants that is not found in animals. However, both glyphosate and Roundup™ are rated as Group 2 A, probably human carcinogens, and also have documented effects on reproduction, acting as endocrine disruptive chemicals. We have reviewed reports of the effects of glyphosate and Roundup™ on the mammalian nervous system function. As with several other herbicides, Roundup™ exposure has been associated with an increased risk of Parkinson’s Disease and death of neurons in the substantia nigra. There is also some evidence implicating Roundup™ in elevated risk of autism. Other studies have shown the effects of Roundup™ on synaptic transmission in animal and cellular studies. The major mechanism of action appears to be oxidative stress, accompanied by mitochondrial dysfunction. In addition, some gut bacteria utilize the enzyme used by plants, and glyphosate and Roundup™ use has been shown to alter the gut microbiome. There is a large and growing body of evidence that the gut microbiome alters susceptibility to great number of human diseases, including nervous system function. The weight of the evidence indicates that in addition to cancer and reproductive effects, glyphosate and Roundup™ have significant adverse effects on the brain and behavior and increase the risk of at least some serious neurological diseases.

Authors: Najm Alsadat Madani, David O Carpenter
; Full Source: Environmental research 2022 Jul 19;113933. doi: 10.1016/j.envres.2022.113933.