Endometriosis is an oestrogen dependent gynaecologic disease with lasting implications for many women’s fertility, somatic health, and overall quality of life. Growing evidence suggests that endocrine disrupting chemicals (EDCs) may be aetiologically involved in the development and severity of disease. The authors weigh the available human evidence focusing on EDCs and endometriosis, restricting to research that has individually quantified chemical concentrations for women, included a comparison group of unaffected women, and used multivariable analytic techniques. Evidence supporting an environmental aetiology for endometriosis includes metals/trace elements, dioxins, and other persistent organic pollutants, as well as nonpersistent chemicals, such as benzophenones and phthalates. To address the equivocal findings for various EDCs, future research directions for filling data gaps include [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”] use of integrated clinical and population sampling frameworks allowing for incorporation of new diagnostic modalities;  the collection of various biologic media, including target tissues for quantifying exposures;  study designs that offer various comparison groups to assess potentially shared aetiologies with other gynaecologic disorders; and  novel laboratory and statistical approaches that fully explore all measured EDCs for the assessment of mixtures and low dose effects and the use of directed acyclic graphs and supporting causal analysis for empirically delineating relationships between EDCs and endometriosis.
Authors: Smarr MM, Kannan K, Buck Louis GM. ;Full Source: Fertility & Sterility. 2016 Jul 15. pii: S0015-0282(16)61389-4. doi: 10.1016/j.fertnstert.2016.06.034. [Epub ahead of print] ;[/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]