Endocrine-Disrupting Chemicals, Risk of Type 2 Diabetes, and Diabetes-Related Metabolic Traits: A Systematic Review and Meta-analysis

Elevated blood or urinary concentrations of endocrine-disrupting chemicals (EDCs) may be related to increased type 2 diabetes (T2D) risk. The objective of this study was to assess the role of EDCs in affecting risk of T2D and related metabolic traits. The authors searched MEDLINE for cross-sectional and prospective studies published before 8 March 2014 for the association between EDCs [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][dioxin, polychlorinated biphenyl (PCB), chlorinated pesticide, bisphenol A (BPA), phthalates] and T2D and related metabolic traits. Three investigators independently extracted information on study design, participant characteristics, EDC types and concentrations, and association measures. Forty-one cross-sectional and 8 prospective studies from ethnically diverse populations were included. Serum concentrations of dioxins, PCBs, and chlorinated pesticides were significantly associated with T2D risk; comparing the highest to the lowest concentration category, the pooled relative risks were 1.91 (95% CI, 1.44 to 2.54) for dioxins, 2.39 (95% CI, 1.86 to 3.08) for total PCBs, and 2.30 (95% CI, 1.81 to 2.93) for chlorinated pesticides. Urinary concentrations of BPA and phthalates were also associated with T2D risk; comparing the highest to the lowest concentration categories, the pooled relative risks were 1.45 (95% CI, 1.13 to 1.87) for BPA and 1.48 (95% CI, 0.98 to 2.25) for phthalates. Further, EDC concentrations were associated with indicators of impaired fasting glucose and insulin resistance. Persistent and non-persistent EDCs may affect the risk of T2D. The authors concluded that there is an urgent need for further investigation of EDCs, especially non-persistent ones, and T2D risk in large prospective studies.

Authors: Song Y, Chou EL, Baecker A, You NY, Song Y, Sun Q, Liu S. ;Full Source: Journal of Diabetes. 2015 Jun 29. doi: 10.1111/1753-0407.12325. [Epub ahead of print] ;[/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]