Epigenetics provides the key to transform the genetic information into phenotype and because of its reversibility it is considered an ideal target for therapeutic interventions. This study reviews the basic mechanisms of epigenetic control: DNA methylation, histone modifications, chromatin remodelling, and ncRNA expression and their role in disease development. The authors also describe the influence of the environment, lifestyle, nutritional habits, and the psychological influence on epigenetic marks and how these factors are related to cancer and other diseases development. Finally, the potential use of natural epigenetic modifiers in the chemoprevention of cancer to link together public health, environment, and lifestyle are discussed.
Authors: Romani M, Pistillo MP, Banelli B. ;Full Source: Biomedical Research International. 2015;2015:587983. doi: 10.1155/2015/587983. Epub 2015 Aug 3. ;