Exposure to indoor pollutants and Wheeze and asthma development during early childhood

This review aimed to summarise existing epidemiological evidence of the association between quantitative estimates of indoor air pollution with early childhood respiratory disease. The authors carried out a systematic literature search of peer-reviewed epidemiological studies undertaken in “westernised” countries that have assessed exposure to indoor pollutants and asthma and wheeze from infancy up to the age of 5. The search, between January 2004 and February 2014 yielded 1840 studies for consideration. Following application of eligibility criteria to titles and abstracts 22 independent studies were deemed relevant for further review. Two additional studies were next identified through examination of the references’ lists of these studies. Of these 24 selected studies, 16 adopted a prospective cohort design and 8 were case-control studies. Fourteen studies assessed exposure to bio-aerosols, 8 studies assessed exposure to specific air chemicals and two studies assessed exposure to bio-aerosols and air chemicals. Furthermore, 11 studies examined the association of exposure with asthma and 16 with wheeze. Findings indicate that existing studies have reported contradictory effects of indoor pollutants levels and occurrence of asthma/wheeze. The authors concluded that additional research to establish causality and evaluate interventions to prevent disease onset is needed.

Authors: Patelarou E, Tzanakis N, Kelly FJ. ;Full Source: International Journal of Environmental Research & Public Health. 2015 Apr 13;12(4):3993-4017. doi: 10.3390/ijerph120403993. ;