Gut Microbiota, Endocrine-Disrupting Chemicals, and the Diabetes Epidemic

Diabetes is rapidly emerging as one of the biggest health concerns worldwide, with profound implications for disability, mortality, and costs. This suddenly escalating rate of diabetes correlates with global industrialisation and the production of plastics, pesticides, synthetic fertilisers, electronic waste, and food additives that release endocrine-disrupting chemicals (EDCs) into the environment and the food chain. Emerging evidence indicates an association between exposure of EDCs and diabetes. In humans, these chemicals are also metabolised by the gut microbiota and thereby their toxicodynamics are altered. In this review the authors highlight studies that focus on the role of gut microbiota in EDC-induced hyperglycaemia and dysregulated glucose homeostasis. In addition, the translational implications of understanding EDC-microbiota interactions for the diagnosis and treatment of diabetes is discussed.

Authors: Velmurugan G, Ramprasath T, Gilles M, Swaminathan K, Ramasamy S. ;Full Source: Trends in Endocrinology & Metabolism. 2017 May 29. pii: S1043-2760(17)30065-6. doi: 10.1016/j.tem.2017.05.001. [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][Epub ahead of print] ;[/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]