Human contamination by persistent toxic substances: the rationale to improve exposure assessment

A lot is known about the generalised human contamination by environmental chemical agents; this statement is fully compatible with the view that most countries lack the necessary monitoring systems. In addition, quite a lot is known about the toxic effects of environmental pollutants; this statement is fully compatible with the proposal that we need both more research and more energetic policies to decrease human contamination by such pollutants. Unsurprisingly, too little is known about the (environmental and social) causes and the etiopathogenesis (mechanisms) of the most prevalent diseases, and we will continue to miss relevant causes and mechanisms if we neglect the toxic chemicals that commonly contaminate humans, worldwide. Basic, clinical end environmental-epidemiological research on human health should more often consider integrating biomarkers of internal dose of environmental chemical pollutants. When we act in more responsible, rational, and scientific ways; when we become less dismissive towards environmental hazards; and when we thus neglect less the generalised human contamination by environmental chemical agents and their toxic effects, we will expand mechanistic biologic knowledge, and we shall as well increase the effectiveness of interventions and policies that enable the primary prevention of human diseases which cause huge amounts of economic burden and human suffering.

Author: Porta M. ;Full Source: Environmental Science & Pollution Research International. 2014 Aug 30. [Epub ahead of print] ;