Due to the worldwide concern that bisphenol A might act as an endocrine disruptor, alternative materials for polycarbonate (PC) have been introduced on the European market. However, PC-replacement products might also release substances of which the toxicological profile – including their genotoxic effects – has not yet been characterised. Because a thorough characterisation of the genotoxic profile of all these substances is impossible in the short term, a strategy was developed in order to prioritise those substances for which additional data are urgently needed. The strategy consisted of a decision tree using hazard information related to genotoxicity. The relevant information was obtained from the database of the European Chemicals Agency (ECHA), in silico prediction tools (ToxTree and Derek NexusTM) and the in vitro Vitotox® test for detecting DNA damage. By applying the decision tree, substances could be classified into different groups, each characterised by a different probability to induce genotoxic effects. Although none of the investigated substances could be unequivocally identified as genotoxic, the presence of genotoxic effects could neither be excluded for any of them. Consequently, all substances require more data to investigate the genotoxic potential. However, the type and the urge for these data differs among the substances.
Authors: Mertens B, Simon C, Van Bossuyt M, Onghena M, Vandermarken T, Van Langenhove K, Demaegdt H, Van Hoeck E, Van Loco J, Vandermeiren K, Covaci A, Scippo ML, Elskens M, Verschaeve L. ;Full Source: Food and Chemical Toxicology. 2016 Jan 20. pii: S0278-6915(16)30009-6. doi: 10.1016/j.fct.2016.01.009. [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][Epub ahead of print] ;[/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]