Ion Mobility Spectrometry: A Comprehensive and Versatile Tool for Occupational Pharmaceutical Exposure Assessment

Qualitative and quantitative capabilities of ion mobility spectrometry (IMS) as a powerful, comprehensive tool to monitor workplace air were demonstrated in a Spanish pharmaceutical company. The developed IMS-based procedure can detect and determine active pharmaceutical ingredients (API) manipulated and/or produced in the air of this pharmaceutical industry. Sensitivity (ng-pg range), selectivity, possibly to provide results in near real-time, and reduction of analysis costs are the most important properties which ratify IMS as a serious alternative for occupational exposure assessment. The possibility of false positives, by drift time interferences, and false negatives, by competitive ionisation and desorption process interferences, were evaluated in detail. Chemometric strategies based on self-modelling curve resolution were used to obtain qualitative and quantitative individual component information from overlapped peaks. The authors concluded that the IMS procedure was successfully used to evaluate API concentrations (nimesulide, dexketoprofen, deflazacort) handled by company employees during production of tablets and granulates; control measures were also suggested.

Authors: Armenta, S.; Blanco, M. ;Full Source: Analytical Chemistry 2012, Ahead of Print (English) ;