Is There an Association Between Ambient Air Pollution and Bladder Cancer Incidence? Analysis of 15 European Cohorts

Ambient air pollution contains low concentrations of carcinogens implicated in the aetiology of urinary bladder cancer (BC). Little is known about whether exposure to air pollution influences BC in the general population. This study evaluated the association between long-term exposure to ambient air pollution and BC incidence. The authors obtained data from 15 population-based cohorts enrolled between 1985 and 2005 in eight European countries (N=303431; mean follow-up 14.1 yr). Exposure to nitrogen oxides (NO2 and NOx), particulate matter (PM) with diameter <10?m (PM10), <2.5?m (PM2.5), between 2.5 and 10?m (PM2.5-10), PM2.5absorbance (soot), elemental constituents of PM, organic carbon, and traffic density at baseline home addresses using standardised land-use regression models from the European Study of Cohorts for Air Pollution Effects project was estimated. The authors used Cox proportional-hazards models with adjustment for potential confounders for cohort-specific analyses and meta-analyses to estimate summary hazard ratios (HRs) for BC incidence. During follow-up, 943 incident BC cases were diagnosed. In the meta-analysis, none of the exposures were associated with BC risk. The summary HRs associated with a 10-?g/m(3) increase in NO2 and 5-?g/m(3) increase in PM2.5 were 0.98 (95% confidence interval [fusion_builder_container hundred_percent="yes" overflow="visible"][fusion_builder_row][fusion_builder_column type="1_1" background_position="left top" background_color="" border_size="" border_color="" border_style="solid" spacing="yes" background_image="" background_repeat="no-repeat" padding="" margin_top="0px" margin_bottom="0px" class="" id="" animation_type="" animation_speed="0.3" animation_direction="left" hide_on_mobile="no" center_content="no" min_height="none"][CI] 0.89-1.08) and 0.86 (95% CI 0.63-1.18), respectively. Limitations include the lack of information about lifetime exposure. The authors concluded that there was no evidence of an association between exposure to outdoor air pollution levels at place of residence and risk of BC. The authors assessed the link between outdoor air pollution at place of residence and bladder cancer using the largest study population to date and extensive assessment of exposure and comprehensive data on personal risk factors such as smoking. No association was found between the levels of outdoor air pollution at place of residence and bladder cancer risk.

Authors: Pedersen M, Stafoggia M, Weinmayr G, Andersen ZJ, Galassi C, Sommar J, Forsberg B, Olsson D, Oftedal B, Krog NH, Aamodt G, Pyko A, Pershagen G, Korek M, De Faire U, Pedersen NL, Östenson CG, Fratiglioni L, Sørensen M, Eriksen KT, Tjønneland A, Peeters PH, Bueno-de-Mesquita B, Vermeulen R, Eeftens M, Plusquin M, Key TJ, Jaensch A, Nagel G, Concin H, Wang M, Tsai MY, Grioni S, Marcon A, Krogh V, Ricceri F, Sacerdote C, Ranzi A, Cesaroni G, Forastiere F, Tamayo I, Amiano P, Dorronsoro M, Stayner LT, Kogevinas M, Nieuwenhuijsen MJ, Sokhi R, de Hoogh K, Beelen R, Vineis P, Brunekreef B, Hoek G, Raaschou-Nielsen O. ; Full Source: European Urology Focus. 2016 Nov 26. pii: S2405-4569(16)30166-3. doi: 10.1016/j.euf.2016.11.008. [Epub ahead of print][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]