Isothiazolinones in commercial products at Danish workplaces

In recent years, a steep increase in the frequency of occupational contact allergy to isothiazolinones has been reported from several European countries. This study examined the extent and occurrence of isothiazolinones in different types of product at Danish workplaces. Seven different isothiazolinones were identified in the Dictionary of Contact Allergens: Chemical Structures, Sources, and References from Kanerva’s Occupational Dermatitis. By use of the chemical names and Chemical Abstracts Service numbers for these chemicals, information on products registered in the Danish Product Register Database (PROBAS) was obtained. All seven isothiazolinones were registered in PROBAS. The top three isothiazolinones registered were: benzisothiazolinone (BIT), registered in 985 products, methylisothiazolinone (MI), registered in 884 products, and methylchloroisothiazolinone (MCI)/MI, registered in 611 products. The concentration ranges were 0.01ppm to 45% for BIT, 0.01ppm to 10% for MI, and 0.01ppm to 14.1% for MCI/MI. The most common product type was ‘paint and varnish’; five of the seven isothiazolinones were registered in this type of product. The authors concluded that isothiazolinones are present in multiple products registered for use at workplaces, and may occur in high concentrations.

Authors: Friis UF, Menn‚ T, Flyvholm MA, Bonde JP, Lepoittevin JP, Le Coz CJ, Johansen JD. ;Full Source: Contact Dermatitis 2014 May 22. doi: 10.1111/cod.12235. [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][Epub ahead of print] ;[/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]