The Threshold of Toxicological Concern (TTC) concept is well established for assessing human safety of food-contact substances and has been reapplied for a variety of endpoints including carcinogenicity, teratogenicity, and reproductive toxicity. The TTC establishes an exposure level for chemicals, below which no appreciable risk to human health or the environment is expected based upon a de minimis value for toxicity identified for many chemicals. TTC approaches have benefits for screening-level risk assessments, including the potential for rapid decision-making, fully utilising existing knowledge, reasonable conservativeness for chemicals used in lower volumes (Low Production Volume Chemicals (LPCVs -e.g.<1 t/yr), and reduction or elimination of unnecessary animal tests. Higher production volume chemicals >1t/yr) would in principle always require specific information due to the presumed higher exposure potential. TTC has found particular favour in the assessment of chemicals used in cosmetics and personal care products as well as other chemicals traditionally used in low volumes. Use of the TTC in environmental safety is just beginning and initial attempts are being published. Key questions focus on hazard extrapolation of diverse taxa across trophic levels, importance of mode of action, and whether safe concentrations for ecosystems estimated from acute or chronic toxicity data are equally useful and in what contexts. This study provided an overview of the theoretical basis for developing an eco-TTC with an initial exploration for chemical assessment and boundary conditions for use. An international collaboration under the ILSI Health and Environmental Sciences Institute has been established to address challenges related to developing and applying useful eco-TTC concepts.
Authors: Belanger SE, Sanderson H, Embry MR, Coady K, DeZwart D, Farr BA, Gutsell S, Halder M, Sternberg R, Wilson P. ;Full Source: Environmental Toxicology & Chemistry. 2015 Jun 25. doi: 10.1002/etc.3132. [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][Epub ahead of print] ;[/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]