Lead toxicity and infertility in female Swiss mice: a review

The present review aimed to accomplish the lacuna by reviewing exposure and health effects of lead manifested in females. Lead compounds are known to adversely affect the various mammalian systems. Reproductive toxicity, which can be defined as the adverse effect of chemicals, lead being one that can affect the gonadal structure and functions, can cause alterations in fertility and impaired gamete function. However reproductive toxicity is comparatively less expedited. The toxicant can also lead to induction of malformations in children, reduce chances of conception, may be embryocidal and cause stillbirth or death of progeny. The toxic effects of lead on adult female reproduction are decreased fertility, the inability to sustain pregnancy and reduced pregnancy outcomes. There is a lack of information concerning whether environmental health effects are more or less prevalent or manifested differently in women compared to men. Previously, most research in the area of toxicological and environmental and occupational health involved male subjects. There is paucity of information about the direct actions of heavy metals on the female reproductive system, fertility and development. Unlike the testes, the ovary has not been as amenable to study.

Authors: Qureshi, Nazera; Sharma, Ragini. ;Full Source: Journal of Chemical, Biological and Physical Sciences 2012, 2(4), 1849-1861 (Eng). ;