Maternal serum levels of perfluoroalkyl substances and organochlorines and indices of foetal growth: a Scandinavian case-cohort study

The associations between prenatal exposure to endocrine disruptive chemicals (EDCs) and foetal growth are inconsistent, and few studies have considered small for gestational age (SGA) birth as an outcome. The current study of Scandinavian parous women aimed to address these inconsistencies and gaps in the literature. This case-cohort study included 424 mother-child pairs who participated in a prospective, multi-centre study of parous women in Norway (Trondheim and Bergen) and Sweden (Uppsala). The authors used linear and logistic regression with 95% confidence intervals (CIs) to analyse the associations between two perfluoroalkyl substances (PFASs) and five organochlorines (OCs) from early second trimester and indices of foetal growth. Among Swedish women, prenatal exposure to perfluorooctanoate (PFOA), polychlorinated biphenyl (PCB) 153 and hexachlorobenzene (HCB) were associated with higher odds for SGA birth. The authors found stronger associations among Swedish male offspring. In the Norwegian cohort, no significant association was found between EDC exposure and indices of foetal growth. Some populations may be more vulnerable to EDCs, possibly due to differences in exposure levels, exposure sources and/or modifiable lifestyle factors. Male offspring may be more vulnerable to endocrine disruption.

Authors: Lauritzen HB, Larose TL, Øien T, Sandanger TM, Odland JØ, van de Bor M, Jacobsen GW. ;Full Source: Pediatric Research. 2016 Sep 22. doi: 10.1038/pr.2016.187. [Epub ahead of print] ;