In this study, the authors discuss the prognostic criteria of developing malignant skin growth in fiberglass production workers using molecular-genetic markers. Thus, DNA is recovered from peripheral venous blood for the purpose of analysing dup16bp polymorphism of intron 3 and Arg72Pro polymorphism of exon 4 of the TP53 gene. If observing the combinations of the *Arg/*Pro and *W/*dup16 genotypes, a risk of developing malignant skin growth is predicted. The authors conclude that the *Arg/*Arg and *W/*W genotypes enables to predict resistance to the onset of the disease.
Authors: Valeeva, E. T.; Bakirov, A. B.; Mukhammadieva, G. F.; Selezneva, L. I.; Karimova, L. K.; Tikhonova, T. P. ;Full Source: FGUN “Ufimskiy NII Meditsiny Truda i Ehkologii Cheloveka” Fed. Sluzhby po Nadzoru v Sfere Zashchity Prav Potrebitelei i Blagopoluchiya Cheloveka, Russia. Russ. RU 2454668 C1 27 Jun 2012, 9pp. (Russian) ;