Modulating the microtubule-tau interactions in biomotility systems by altering the chemical environment

Obstacles in microtubule mediated neuronal transport can trigger dementia. In the present study, the authors used bio-motility assays, that simulate the neuron chemistry in axonopathy, to screen chemicals, that retain the microtubule dynamics in healthy neuronal activity. Tau protein inhibits microtubule activity and leads to oligomerisation. Iron(iii) untangles, whereas mono-sodium-glutamate destabilises the microtubule oligomer.

Authors: Bhattacharyya S, Kim K, Nakazawa H, Umetsu M, Teizer W. ;Full Source: Integrated Biology (Camb). 2016 Oct 27. [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][Epub ahead of print] ;[/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]