Multi-organ toxicity attenuation by cerium oxide and yttrium oxide nanoparticles: comparing the beneficial effects on tissues oxidative damage induced by sub-acute exposure to diazinon


Background: Excessive use of diazinon as an organophosphate pesticide (OP), contributes to cytotoxic and pathologic cellular damage and in particular oxidative stress. However, metal-oxide nanoparticles (NPs) such as cerium oxide (CeO2) and yttrium oxide (Y2O3) with the property of free radical scavenging demonstrated beneficial effects in alleviation of oxidative stress biomarkers.

Objective: The aims of this study include to evaluate beneficial effects of CeO2 NPs, Y2O3 NPs and their combination against diazinon-induced oxidative stress in different tissues consisting of brain, heart, lung, kidney, liver and spleen.

Methods: Eight randomized groups of 6 adult male Wistar rats were formed. Each group of rats administered different combination of diazinon, CeO2 and Y2O3 NPs daily and levels of oxidative stress markers such as reactive oxygen species (ROS), lipid peroxidation (LPO), total thiol molecules (TTM) and total antioxidant power (TAP) and catalase enzyme were measured after 2 weeks of the treatment.

Results: Measurements of the mentioned markers in brain, heart, lung, kidney, liver and spleen showed that administration of NPs can significantly alleviate the oxidative stress induced by diazinon. However, findings of this study illustrated that the combination of both CeO2 and Y2O3 NPs led to better reduction in oxidative stress markers. Conclusion: Sub-acute exposure of diazinon in rats led to increased levels of oxidative stress markers in pivotal tissues such as brain, heart, lung, kidney, liver and spleen. CeO2 and Y2O3 NPs neutralize the oxidative stress to compensate diazinon-induced tissue damages.

Authors: Mohammad Reza Khaksar, Mona Navaei-Nigjeh, Marzieh Daniali, Mahban Rahimifard
; Full Source: Pharmaceutical nanotechnology 2020 Aug 8. doi: 10.2174/2211738508666200808135226.