In this study, the authors aimed to develop orally active drugs with these effects, but it is convenient to examine more closely what we are eating. If a lack of relevance in terms of toxicity and substantial effectiveness are confirmed, plant-derived components may provide useful druggable components and dietary supplements. The convergence of pathways involving the immune response, oxidative stress, increased circulating lipids and aberrant insulin signalling results in CCL2-associated macrophage recruitment and altered energy metabolical. The CCL2/CCR2 pathway and the energy sensor AMP-activated protein kinase (AMPK) are attractive therapeutic targets as a part of preventive management of disease. Several effects of polyphenols are useful in this scenario, including a reduction in the activities of cytokines and modulation of cellular metabolical through histone deacetylase inhibitors, AMPK activators, calorie-restriction mimetics or epigenetic regulators. The author concluded improvement in food through enrichment with polyphenols with demonstrated activity may represent a major advance in the design of diets with both industrial and sanitary value.
Authors: Joven, J.; Rull, A.; Rodriguez-Gallego, E.; Camps, J.; Riera-Borrull, M.; Hernandez-Aguilera, A.; Martin-Paredero, V.; Segura-Carretero, A.; Micol, V.; Alonso-Villaverde, C.; Menendez, J. A. ;Full Source: Food and Chemical Toxicology 2013, 51, 267-279 (English) ;