Neutrophils life under estrogenic and xenoestrogenic control

Over 100 years ago, scientists had identified cells that represent the most abundant population of peripheral blood leukocytes; they called this population neutrophils. Day by day, the knowledge specific to neutrophils is augmented with new and often surprising aspects and facts about neutrophils’ life or death. Oestrogens (oestrone, oestriol, and oestradiol) are relevant for the regulation of immune responses that are related with neutrophils. An understanding of the molecular mechanism of the action of endogenous hormones allows us to predict the effects of the substances that commonly occur in an environment with oestrogen-like properties (xenoestrogens (e.g., bisphenol A, DDT, tributyltin, polychlorinated biphenyls, nonylphenol and octylphenol)). Therefore, in the present study, the authors summarise current literature on the impact of oestrogens and xenoestrogens, on each aspect of neutrophil life, as well as describe its mechanism of actions in neutrophils.

Authors: Nowak K, Jab?o?ska E, Ratajczak-Wrona W. ; Full Source: Journal of Steroid Biochemistry and Molecular Biology. 2018 Oct 28. pii: S0960-0760(18)30537-5. doi: 10.1016/j.jsbmb.2018.10.015. [Epub ahead of print]