Non-phthalate plasticizers in German daycare centres and human biomonitoring of DINCH metabolites in children attending the centres (LUPE 3).

Plasticisers have been widely used for decades as additives in diverse applications, including consumer and building products, toys, cables, and floorings. Due to toxicological concerns and restrictions of different dialkyl ortho-phthalates, other plasticisers have been increasingly used in recent years. Therefore, di-isononyl cyclohexane-1,2-dicarboxylate (DINCH), di(2-ethylhexyl) terephthalate (DEHT), di(2-ethylhexyl) adipate (DEHA), acetyl tri-n-butyl citrate (ATBC), and trioctyl trimellitate (TOTM) plasticiser levels in indoor air and dust samples from 63 daycare centres in Germany were measured. Moreover, the urine samples of 208 children who attend 27 of these facilities were analysed for the presence of four DINCH metabolites. DINCH, DEHT, and DEHA were present in indoor air with median values of 108ng/m(3), 20ng/m(3), and 34ng/m(3), respectively. Median values of 302mg/kg for DINCH, 49mg/kg for DEHA, 40mg/kg for DEHT, and 24mg/kg ATBC were found in dust. In the urine samples, the three secondary metabolites of DINCH were observed with median values (95th percentiles) of 1.7?g/l (10.0?g/l) for OH-MINCH, 1.5?g/l (8.0?g/l) for oxo-MINCH, and 1.1?g/l (6.1?g/l) for cx-MINCH. Overall, these metabolite levels are orders of magnitude lower than the current HBM I values set by the German Human Biomonitoring Commission. Using general exposure assumptions, the intake resulting from dust ingestion and inhalation is low for children. The total daily DINCH intake calculated from biomonitoring data was 0.5?g/kg b.w. using median values and 9.8?g/kg b.w. as the maximum value. At present, non-phthalate plasticisers, especially DINCH, can be found in considerable amounts in dust samples from daycare centres and as DINCH metabolites in the urine of children. In relation to previous studies, the concentrations of DINCH in dust and urine have an increasing time trend. Compared with tolerable daily intake values, the total daily intake of DINCH reached only 1% of its maximum value to date; however, due to its increased use, higher exposure of DINCH is expected in the future.

Authors: Fromme H, Schütze A, Lahrz T, Kraft M, Fembacher L, Siewering S, Burkardt R, Dietrich S, Koch HM, Völkel W. ;Full Source: International Journal of Hygiene & Environmental Health. 2015 Aug 7. pii: S1438-4639(15)00103-0. doi: 10.1016/j.ijheh.2015.08.002. [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][Epub ahead of print] ;[/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]