The skin is frequently exposed to environmental challenges, such as UV irradiation, toxic chemicals or mechanical wounding. These insults cause an increase in the levels of reactive oxygen species, resulting in oxidative stress and concomitant inflammation, skin aging and even cancer development. Therefore, an efficient antioxidant defence strategy is of major importance in this tissue. Since the NRF2 transcription factor regulates a battery of genes involved in the defence against reactive oxygen species and in compound metabolism, it plays a key role in skin homeostasis, repair and disease. In this review the authors summarise the current knowledge on the expression and function of NRF2 in normal skin, its role in the acute and chronic UV response as well as in the pathogenesis of epithelial skin cancer and of different inflammatory skin diseases. Finally, the authors discuss the potential of NRF2-activating compounds for skin protection under stress conditions and for the treatment of major human skin disorders.
Authors: Schäfer M, Werner S. ;Full Source: Free Radical Biology & Medicine. 2015 Apr 22. pii: S0891-5849(15)00181-1. doi: 10.1016/j.freeradbiomed.2015.04.018. [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][Epub ahead of print] ;[/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]