Occupational exposures to chemicals as a possible aetiology in premature ovarian failure: A critical analysis of the literature

Premature ovarian failure (POF) is a cause of infertility that affects about 1% of women under 40, and is considered as idiopathic in 75% of cases. Previous research has identified an occupational chemical origin, at least once with 2-bromopropane, but human studies are rare and experimental data are sparse. This review conducted a critical synthesis of knowledge of the chemical agents likely to affect follicular stock in humans and/or animals, by direct toxicity to follicles, or by increasing their recruitments. Out of 140 chemical agents (or groups) studied, 20 have been identified as potentially damaging to the ovarian reserve. For the majority of toxic agents, only experimental data are currently available. At least four of these agents are likely to lead to POF in descendents (ethylene glycol Me ether; 2,2-bis(bromomethyl)-1,3-propanediol; benzo[fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][a]pyrene; dimethylbenzantracene). The authors propose a strategy aiming to encourage progress in identifying occupational factors responsible for POF.

Authors: Beranger, Remi; Hoffmann, Pascale; Christin-Maitre, Sophie; Bonneterre, Vincent ;Full Source: Reproductive Toxicology 2012, 33(3), 269-279 (English) ;