Optical clearing for OCT image enhancement and in-depth monitoring of molecular diffusion

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In this paper, the authors reviewed the basic principles, recent results, advantages, limitations, and future of the optical clearing method in application to many fields of biological and medicine. In addition, they discussed the possibility of non-invasive assessment of molecular diffusion in tissues using the optical coherence tomography technique. Issues of safety and toxicity of application of different endogenous and exogenous molecular to tissues are outlined.

Authors: Larin, Kirill V.; Ghosn, Mohamad G.; Bashkatov, Alexey N.; Genina, Elina A.; Trunina, Natalia A.; Tuchin, Valery V. ;Full Source: Journal of Selected Topics in Quantum Electronics 2012, 18(3), 1244-1259 (Eng) ;