To satisfy REACH requirements a high number of data on chemical of interest should be supplied to the European Chemicals Agency. To organise the various kinds of information and help the registrants to choose the best strategy to obtain the needed information limiting at the minimum the use of animal testing, integrated testing strategies (ITSs) schemes can be used. The present study deals with regulatory data requirements for assessing the hazards of chemicals to the aquatic pelagic environment. The present an ITS scheme for organising and using the complex existing data available for aquatic toxicity assessment. An ITS to optimise the choice of the correct prediction strategy for aquatic pelagic toxicity is described. All existing information (like physico-chemical information), and all the alternative methods (like in silico, in vitro or the acute-to-chronic ratio) are considered. Moreover the weight of evidence approach to combine the available data is included.
Authors: Lombardo A, Roncaglioni A, Benfenati E, Nendza M, Segner H, Jeram S, Pauné E, Schüürmann G. ;Full Source: Environmental Research. 2014 Sep 25;135C:156-164. doi: 10.1016/j.envres.2014.09.002. [Epub ahead of print] ;