Organobromine compound profiling in human adipose: Assessment of sources of bromophenol

Bromophenols (BRPs) have been widely detected in human tissues, however, relative proportions from natural products and/or anthropogenic flame retardants are not clear. In this study, the authors simultaneously quantified 21 polybrominated diphenyl ethers (PBDEs), 15 MeO/OH-PBDEs, and 10 BRPs in adipose collected from people from New York City, USA. An in vitro assay utilising human liver microsomes was performed for detected predominant organobromine. High concentrations of 2,4,6-triBRP and PBDEs were observed, and extremely low concentrations of naturally occurring MeO/OH-PBDEs were detected. Similar biotransformatioin rates of BRPs and MeO/OH-PBDEs indicated that the relative high concentration of 2,4,6-triBRP in humans was not of natural origin. Significant correlation observed between concentrations of 2,4,6-triBRP and BDE-209 suggested that the two chemicals may share a common source. Both 2,4,6-triBRP and BDE-209 were detected in commercial ABS resins, suggesting that plastic products made from ABS resins could be potential sources of co-exposure of the two compounds for humans.

Authors: Gao S, Wan Y, Zheng G, Luo K, Kannan K, Giesy JP, Lam MH, Hu J. ;Full Source: Environmental Pollution. 2015 Apr 29;204:81-89. doi: 10.1016/j.envpol.2015.04.015. [Epub ahead of print] ;